Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis.

@article{Lee2009RoleOP,
  title={Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis.},
  author={Jung Rok Lee and Jae Kyung Kim and Soo Jae Lee and Kwang Pyo Kim},
  journal={Archives of pharmacal research},
  year={2009},
  volume={32 8},
  pages={1109-18}
}
Nitric oxide generates reactive nitrosative species, such as peroxynitrite (ONOO(-)) that may be involved in a number of diseases. ONOO(-) can mediate protein tyrosine nitration which causes structural changes of affected proteins and leads to their inactivation. Various proteomics and immunological methods including mass spectrometry combined with both… CONTINUE READING