Role of protein phosphatases in estrogen-mediated neuroprotection.

  title={Role of protein phosphatases in estrogen-mediated neuroprotection.},
  author={Kun Yi and Jaegwon Chung and Priscilla Pang and James William Simpkins},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 31},
The signaling pathways that mediate neurodegeneration are complex and involve a balance between phosphorylation and dephosphorylation of signaling and structural proteins. We have shown previously that 17beta-estradiol and its analogs are potent neuroprotectants. The purpose of this study was to delineate the role of protein phosphatases (PPs) in estrogen neuroprotection against oxidative stress and excitotoxicity. HT-22 cells, C6-glioma cells, and primary rat cortical neurons were exposed to… CONTINUE READING


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