Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding.

@article{Jetten1985RoleOP,
  title={Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding.},
  author={Anton M Jetten and B R Ganong and G R Vandenbark and J. E. J. Shirley and R M Bell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 7},
  pages={1941-5}
}
Tumor-promoting phorbol esters induce ornithine decarboxylase (ODCase) activity and reduce epidermal growth factor (EGF) binding in rat tracheal epithelial 2C5 cells. Phorbol esters activate protein kinase C by interacting at the same site as sn-1,2-diacylglycerols, the presumed physiological regulators. The effects of added sn-1,2-diacylglycerols and those generated by phospholipase C treatment of 2C5 cells on ODCase induction and EGF binding were investigated to establish a role for protein… CONTINUE READING

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