Role of protein kinase C in chick embryo skeletal myoblast fusion.

@article{David1990RoleOP,
  title={Role of protein kinase C in chick embryo skeletal myoblast fusion.},
  author={John PR David and C R Faser and Georges Perrot},
  journal={Developmental biology},
  year={1990},
  volume={139 1},
  pages={89-99}
}
The involvement of Ca2+ and PGE1 in myoblast fusion has been well documented. Extracellular Ca2+ is essential for myoblast adhesion, alignment, and fusion. There is an obligatory increase in Ca2+ influx immediately preceding fusion and the Ca2+ ionophore A23187 promotes precocious fusion. PGE1 receptors appear just prior to fusion, and an antagonist of PGE1 binding to cell surface receptors blocks fusion when added prior to Ca2+ influx. Finally, exogenous PGE1 induces precocious fusion. The… CONTINUE READING