Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells.

@article{Izquierdo1992RoleOP,
  title={Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells.},
  author={M. Ebroul Izquierdo and Julian Downward and Jonathan D. Graves and Doreen A Cantrell},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 7},
  pages={
          3305-12
        }
}
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in the active GTP-bound state. Stimulation of protein kinase C (PKC) can also activate p21ras, and it has been proposed that the TCR effect on p21ras occurs as a consequence of TCR regulation of PKC. To test the role of PKC in TCR regulation of p21ras, a permeabilized cell system was used to examine TCR regulation of p21ras under conditions in which TCR activation of PKC was blocked, first by using… CONTINUE READING
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