Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection.

@article{Obal2005RoleOP,
  title={Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection.},
  author={Detlef Obal and N. C. Weber and Kai Zacharowski and Octavian Toma and Saskia Dettwiler and Jessica Ilona Wolter and Marita Kratz and Jost Muellenheim and Benedikt Preckel and Wolfgang Schlack},
  journal={British journal of anaesthesia},
  year={2005},
  volume={94 2},
  pages={
          166-73
        }
}
BACKGROUND Volatile anaesthetics precondition the heart against infarction, an effect partly mediated by activation of the epsilon isoform of protein kinase C (PKCepsilon). We investigated whether cardioprotection by activation of PKCepsilon depends on the isoflurane concentration. METHODS Anaesthetized rats underwent 25 min of coronary artery occlusion followed by 120 min of reperfusion and were randomly assigned to the following groups (n=10 in each group): isoflurane preconditioning… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Isoflurane Preconditioning Confers Cardioprotection by Activation of ALDH2

  • PloS one
  • 2013
VIEW 14 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Does pharmacological conditioning with the volatile anaesthetic sevoflurane offer protection in liver surgery?

  • HPB : the official journal of the International Hepato Pancreato Biliary Association
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

'Conditioning' the heart during surgery.

  • European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2009
VIEW 2 EXCERPTS
CITES BACKGROUND

Similar Papers

Loading similar papers…