Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus.

@article{Deutsch2004RoleOP,
  title={Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus.},
  author={Einat Bokobza Deutsch and Adina Cohen and Gila Kazimirsky and Sara Dovrat and Hadara Rubinfeld and Chaya Brodie and Ronit Sarid},
  journal={Journal of virology},
  year={2004},
  volume={78 18},
  pages={10187-92}
}
TPA (12-O-tetradecanoylphorbol-13-acetate), a well-known activator of protein kinase C (PKC), can experimentally induce reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) in certain latently infected cells. We selectively blocked the activity of PKC isoforms by using GF 109203X or rottlerin and demonstrated that this inhibition largely decreased lytic KSHV reactivation by TPA. Translocation of the PKCdelta isoform was evident shortly after TPA stimulation. Overexpression of the… CONTINUE READING