Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells.

@article{Kaur2005RoleOP,
  title={Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells.},
  author={Surinder Kaur and Simrit Parmar and Jessica B Smith and Efstratios Katsoulidis and Yongzhong Li and Antonella Sassano and Beata Majchrzak and Shahab Uddin and Martin S. Tallman and Eleanor N Fish and Leonidas C. Platanias},
  journal={Experimental hematology},
  year={2005},
  volume={33 5},
  pages={550-7}
}
OBJECTIVE The mechanisms by which interferon alpha (IFN-alpha) induces antileukemic responses in chronic myelogenous leukemia (CML) cells are not known. We examined whether a member of the protein kinase C (PKC) family of proteins, PKC-delta, is activated during treatment of BCR-ABL cells with IFN-alpha and participates in the induction of interferon responses. METHODS Immunoblots and immune complex kinase assays were performed to study the phosphorylation and activation of PKC-delta in… CONTINUE READING

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