Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.

@article{Rajotte1992RoleOP,
  title={Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.},
  author={Daniel Rajotte and Paola Haddad and Andr{\'e} Haman and Edward J. Cragoe and Thuong Hoang},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 14},
  pages={9980-7}
}
Granulocyte macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3) suppress apoptosis in hemopoietic cells, a process of active cell death characterized by the degradation of genomic DNA into oligonucleosomic fragments. The present study was therefore initiated with the view that the two growth factors may trigger the same early events in the cell, leading to suppression of apoptosis. We provide evidence here for a role of protein kinase C and of the Na+/H+ antiporter in the… CONTINUE READING
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