Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis.

@article{Holzhausen2005RoleOP,
  title={Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis.},
  author={Marinella Holzhausen and Lu{\'i}s Carlos Spolid{\'o}rio and Nathalie Vergnolle},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2005},
  volume={100 Suppl 1},
  pages={177-80}
}
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that… CONTINUE READING

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