Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor.

@article{Bromberg2001RoleOP,
  title={Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor.},
  author={Michael E. Bromberg and Manuella Bailly and William H. Konigsberg},
  journal={Thrombosis and haemostasis},
  year={2001},
  volume={86 5},
  pages={1210-4}
}
Tissue factor (TF) is a transmembrane glycoprotein that complexes with factor VIIa to initiate blood coagulation. We previously reported that expression of high levels of TF in a human melanoma cell line promotes metastasis. Both the cytoplasmic domain of TF and its extracellular domain complexed with factor VIIa are required for the metastatic effect. To further explore the mechanism of TF-mediated metastasis, we investigated the possibility that a protease-activated receptor (PAR) might play… CONTINUE READING