Role of prostaglandins in renal sensory receptor activation by substance P and bradykinin.

@article{Kopp1993RoleOP,
  title={Role of prostaglandins in renal sensory receptor activation by substance P and bradykinin.},
  author={Ulla C. Kopp and Lori A. Smith},
  journal={The American journal of physiology},
  year={1993},
  volume={265 3 Pt 2},
  pages={R544-51}
}
In anesthetized rats increasing ureteral pressure results in an increase in ipsilateral afferent renal nerve activity and a reflex increase in contralateral urine flow rate and urinary sodium excretion that is dependent on intact prostaglandin synthesis. Activation of renal pelvic substance P receptors contributes to the renorenal reflex responses to increased ureteral pressure. Because these data suggested that renal sensory receptors could be activated by both prostaglandins and substance P… CONTINUE READING