Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament.

@article{Ohishi2003RoleOP,
  title={Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament.},
  author={Hirotaka Ohishi and Ken-ichi Furukawa and Koei Iwasaki and Kazumasa Ueyama and Akihiro Okada and Shigeru Motomura and Seiko Harata and Satoshi Toh},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={305 3},
  pages={818-24}
}
Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments, and mechanical stress has been suggested to play an important role in the progression of OPLL. To identify the genes that participate in OPLL, the differential display reverse transcription-polymerase chain reaction (RT-PCR) method was used. A 283-base pair cDNA fragment corresponding to prostaglandin I2 (PGI2) synthase was highly expressed in OPLL cells… CONTINUE READING