Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.

@article{Yang2001RoleOP,
  title={Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.},
  author={Hong Yang and Z Z Huang and Zhilan Zeng and Chun Chen and Robert Rick Selby and Shao Chun Lu},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={280 2},
  pages={G184-90}
}
Methionine adenosyltransferase (MAT), an essential enzyme that catalyzes the formation of S-adenosylmethionine (SAM), is encoded by two genes, MAT1A (liver-specific) and MAT2A (non-liver-specific). We showed a switch from MAT1A to MAT2A expression in human liver cancer, which facilitates cancer cell growth. The present work examined the role of methylation in MAT2A transcriptional regulation. We found that the human MAT2A promoter is hypomethylated in hepatocellular carcinoma, in which the gene… CONTINUE READING