Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure.

@article{Stravitz2013RoleOP,
  title={Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure.},
  author={Richard Todd Stravitz and Regina Bowling and Robert L. Bradford and Nigel S Key and Sam L Glover and Leroy R. Thacker and Don Alexander Gabriel},
  journal={Hepatology},
  year={2013},
  volume={58 1},
  pages={304-13}
}
UNLABELLED Microparticles (MPs), membrane fragments of 0.1-1.0 μm, are derived from many cell types in response to systemic inflammation. Acute liver failure (ALF) is a prototypical syndrome of systemic inflammatory response syndrome (SIRS) associated with a procoagulant state. We hypothesized that patients with ALF develop increased procoagulant MPs in proportion to the severity of systemic complications and adverse outcome. Fifty patients with acute liver injury (ALI), 78% of whom also had… CONTINUE READING