Role of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors?

@article{Zamponi2009RoleOP,
  title={Role of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors?},
  author={Gerald W Zamponi and Peter K. Stys},
  journal={Prion},
  year={2009},
  volume={3 4},
  pages={187-9}
}
There is increasing evidence that cellular prion protein plays important roles in neurodegeneration and neuroprotection. One of the possible mechanism by which this may occur is a functional inhibition of ionotropic glutamate receptors, including N-Methyl-D-Aspartate (NMDA) receptors. Here we review recent evidence implicating a possible interplay between NMDA receptors and prions in the context of neurodegenerative disorders. Such is a functional link between NMDA receptors and normal prion… CONTINUE READING

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