Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies.

@article{Invernizzi2004RoleOP,
  title={Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies.},
  author={Roberto William Invernizzi and Silvio Garattini},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2004},
  volume={28 5},
  pages={819-27}
}
The therapeutic effect of an antidepressant drug takes at least 2 to 3 weeks to develop and a significant proportion of patients have no or only partial benefit regardless of the class of antidepressant used. Research into the neurobiological basis of antidepressant action has suggested new strategies to improve the antidepressant effect. Recent microdialysis studies show that hypofunction of the presynaptic autoreceptors enhances the increase of extracellular serotonin (5-HT) induced by… CONTINUE READING

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