Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats.

@article{Mori2004RoleOP,
  title={Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats.},
  author={Takefumi Mori and Allen W. Cowley},
  journal={Hypertension},
  year={2004},
  volume={43 4},
  pages={752-9}
}
Renal perfusion pressure was servo-controlled chronically in rats to quantify the relative contribution of elevated arterial pressure versus angiotensin II (Ang II) on the induction of renal injury in Ang II-induced hypertension. Sprague-Dawley rats fed a 4% salt diet were administered Ang II for 14 days (25 ng/kg per minute IV; saline only for sham rats), and the renal perfusion pressure to the left kidney was continuously servo-controlled to maintain a normal pressure in that kidney… CONTINUE READING