Role of premature leptin surge in obesity resulting from intrauterine undernutrition.

  title={Role of premature leptin surge in obesity resulting from intrauterine undernutrition.},
  author={Shigeo Yura and Hiroaki Itoh and Norimasa Sagawa and Hiroshi Yamamoto and Hiroaki Masuzaki and Kazuwa Nakao and Makoto Kawamura and Maki Takemura and Kazuyo Kakui and Yoshihiro Ogawa and Shingo Fujii},
  journal={Cell metabolism},
  volume={1 6},
Intrauterine undernutrition is closely associated with obesity related to detrimental metabolic sequelae in adulthood. We report a mouse model in which offspring with fetal undernutrition (UN offspring), when fed a high-fat diet (HFD), develop pronounced weight gain and adiposity. In the neonatal period, UN offspring exhibited a premature onset of neonatal leptin surge compared to offspring with intrauterine normal nutrition (NN offspring). Unexpectedly, premature leptin surge generated in NN… CONTINUE READING
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