Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging

@article{Valle2001RoleOP,
  title={Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging},
  author={Monique Vall{\'e}e and Willy Mayo and Michel le Moal},
  journal={Brain Research Reviews},
  year={2001},
  volume={37},
  pages={301-312}
}
Aging is a general process of functional decline which involves in particular a decline of cognitive abilities. However, the severity of this decline differs from one subject to another and inter-individual differences have been reported in humans and animals. These differences are of great interest especially as concerns investigation of the neurobiological factors involved in cognitive aging. Intensive pharmacological studies suggest that neurosteroids, which are steroids synthesized in the… Expand
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Dehydroepiandrosterone: A neuroactive steroid
TLDR
A short overview of the possible actions of dehydroepiandrosterone and its sulfate in the brain is presented, calling attention to various mechanisms of their action as neurosteroids and to prospects for the knowledge of their role in brain disorders. Expand
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TLDR
Findings from clinical studies have revealed that PREG, DHEA, and their sulfates might be involved in the pathophysiology of schizophrenia, and in some of its manifestations. Expand
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TLDR
The findings suggest that the mechanism of action of DHEA in the brain can involve a "crosstalk" cellular signaling system that involves both nongenomic and genomic components. Expand
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TLDR
This current study attempts to address the natural history of adrenal hormones by presenting non-human primate evidence of the endocrinology of aging; the age-related patterns of Adrenal hormone decline in three species of the subfamily Cercopithecinae, Macaca mulatta,Macaca nemestrina, and Papio cynocephalus are compared. Expand
Reduced sulfotransferase SULT2A1 activity in patients with Alzheimer's disease.
TLDR
Low ratios of steroid conjugates to their unconjugated counterparts (C/U) demonstrate an association between attenuated sulfation of C19 steroids in adrenal zona reticularis and the pathophysiology of AD. Expand
Immunohistochemical analysis of a novel dehydroepiandrosterone sulfotransferase-like protein in Drosophila neural circuits.
TLDR
Investigation of whether or not cytosolic ST is expressed in the Drosophila nervous system found the presence of dehydroepiandrosterone (DHEA) ST-like protein to be abundant in specific neurons as well as in several bundles of nerve fibers in Dosophila. Expand
In vitro metabolism of dehydroepiandrosterone (DHEA) to 7α-hydroxy-DHEA and Δ5-androstene-3β,17β-diol in specific regions of the aging brain from Alzheimer’s and non-demented patients
Abstract The description of dehydroepiandrosterone (DHEA) as a neuroactive neurosteroid has raised the important question of whether the steroid itself and/or its metabolite(s) are active in the… Expand
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