Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging

  title={Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging},
  author={Monique Vall{\'e}e and Willy Mayo and Michel le Moal},
  journal={Brain Research Reviews},

Central Administration of a Cytochrome P450-7B Product 7α-Hydroxypregnenolone Improves Spatial Memory Retention in Cognitively Impaired Aged Rats

Evidence is provided for a biologically active enzyme product 7α-hydroxyPREG and suggests that reduced CYP7B function in the hippocampus of memory-impaired aged rats may, in part, be overcome by administration of 7 α-hydroxylated metabolite PREG.

Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer’s Disease Diagnosis

The cumulative evidence for oxidative stress as a natural regulator of DHEA formation is presented and the use of this concept to develop a blood-based diagnostic tool for neurodegenerative diseases linked to oxidative stress, such as AD is developed.

Dehydroepiandrosterone: A neuroactive steroid

Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity.

The findings suggest that the mechanism of action of DHEA in the brain can involve a "crosstalk" cellular signaling system that involves both nongenomic and genomic components.

Dehydroepiandrosterone-sulfate as a biomarker of senescence in male non-human primates

Reduced sulfotransferase SULT2A1 activity in patients with Alzheimer's disease.

Low ratios of steroid conjugates to their unconjugated counterparts (C/U) demonstrate an association between attenuated sulfation of C19 steroids in adrenal zona reticularis and the pathophysiology of AD.



Dehydroepiandrosterone Sulphate (DHEAS) in the Oldest Old, Aged 85 and Over a

DHEAS is one of the few compounds that shows a gradual decrease with advancing age, reaching an asymptotic low at the age of the maximum recorded life span and many uncertainties concerning the role of DHEAS in the neuro-immuno-endocrine network have yet to be unravelled.

Pregnenolone sulfate antagonizes dizocilpine amnesia: role for allopregnanolone

It is possible to suggest that the increase in the brain content of ALLO, rather than 5α-DHP, mediates the effect of PREG sulfate on dizocilpine- or CPPene-induced cognition deficit.

Cytochrome P450 in the Brain: Neuroendocrine Functions

The data pertaining to the role of brain P450 in the synthesis and degradation of neurosteroids is examined to answer the following questions: Does P450scc in the brain contribute significantly to the synthesis of GABAA receptor active steroids?