Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging
@article{Valle2001RoleOP, title={Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging}, author={Monique Vall{\'e}e and Willy Mayo and Michel le Moal}, journal={Brain Research Reviews}, year={2001}, volume={37}, pages={301-312} }
204 Citations
Exogenous dehydroisoandrosterone sulfate reverses the dendritic changes of the central neurons in aging male rats
- BiologyExperimental Gerontology
- 2014
Central Administration of a Cytochrome P450-7B Product 7α-Hydroxypregnenolone Improves Spatial Memory Retention in Cognitively Impaired Aged Rats
- Biology, PsychologyThe Journal of Neuroscience
- 2006
Evidence is provided for a biologically active enzyme product 7α-hydroxyPREG and suggests that reduced CYP7B function in the hippocampus of memory-impaired aged rats may, in part, be overcome by administration of 7 α-hydroxylated metabolite PREG.
Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer’s Disease Diagnosis
- Biology, MedicineFront. Endocrin.
- 2011
The cumulative evidence for oxidative stress as a natural regulator of DHEA formation is presented and the use of this concept to develop a blood-based diagnostic tool for neurodegenerative diseases linked to oxidative stress, such as AD is developed.
Dehydroepiandrosterone: A neuroactive steroid
- Biology, MedicineThe Journal of Steroid Biochemistry and Molecular Biology
- 2015
The clinical and therapeutic potentials of dehydroepiandrosterone and pregnenolone in schizophrenia
- Medicine, PsychologyNeuroscience
- 2011
Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity.
- BiologyJournal of neurobiology
- 2003
The findings suggest that the mechanism of action of DHEA in the brain can involve a "crosstalk" cellular signaling system that involves both nongenomic and genomic components.
Dehydroepiandrosterone-sulfate as a biomarker of senescence in male non-human primates
- Biology, MedicineExperimental Gerontology
- 2003
Reduced sulfotransferase SULT2A1 activity in patients with Alzheimer's disease.
- Biology, MedicinePhysiological research
- 2015
Low ratios of steroid conjugates to their unconjugated counterparts (C/U) demonstrate an association between attenuated sulfation of C19 steroids in adrenal zona reticularis and the pathophysiology of AD.
Immunohistochemical analysis of a novel dehydroepiandrosterone sulfotransferase-like protein in Drosophila neural circuits.
- BiologyBiochemical and biophysical research communications
- 2008
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