Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.

@article{Kubota2015RoleOP,
  title={Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.},
  author={Akira Kubota and Jared V. Goldstone and Benjamin Lemaire and Matthew Takata and Bruce R. Woodin and John J. Stegeman},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={143 2},
  pages={398-407}
}
Ligand-activated receptors regulate numerous genes, and mediate effects of a broad set of endogenous and exogenous chemicals in vertebrates. Understanding the roles of these transcription factors in zebrafish (Danio rerio) is important to the use of this non-mammalian model in toxicological, pharmacological, and carcinogenesis research. Response to a potential agonist for the pregnane X receptor (Pxr) [pregnenolone (PN)] was examined in developing zebrafish, to assess involvement of Pxr in… CONTINUE READING
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