Role of potassium channels in amyloid-induced cell death.

@article{Colom1998RoleOP,
  title={Role of potassium channels in amyloid-induced cell death.},
  author={Luis V. Colom and Mar{\'i}a Eugenia Molina D{\'i}az and David R. Beers and A. D. Neely and Wan Jun Xie and Stanley H. Appel},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 5},
  pages={1925-34}
}
Basal forebrain cholinergic neurons are severely depleted early in Alzheimer's disease and appear particularly susceptible to amyloid beta-peptide (A beta) toxicity in vivo. To model this effect in vitro, a cholinergic septal cell line (SN56) was exposed to A beta. SN56 cells exhibited a tetraethylammonium (TEA)-sensitive outward K+ current with delayed rectifier characteristics. Increases of 64% (+/-19; p < 0.02) and 44% (+/-12; p < 0.02) in K+ current density were noted 6-12 and 12-18 h… CONTINUE READING

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