Role of porins in outer membrane permeability.

@article{Hancock1987RoleOP,
  title={Role of porins in outer membrane permeability.},
  author={Robert E W Hancock},
  journal={Journal of bacteriology},
  year={1987},
  volume={169 3},
  pages={
          929-33
        }
}
It is now well recognized that the outer membranes of gram-negative bacteria serve as molecular sieves which permit the passage of small hydrophilic molecules of sizes below a given cutoff, i.e., the exclusion limit (21, 27). This sieving property, which permits uptake of small substrate molecules but excludes potentially harmful enzymes and other large hydrophilic molecules, is due to a class of proteins called porins (21). Porins form trans-outermembrane, water-filled channels, the dimensions… CONTINUE READING
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