Role of polymorphonuclear cells in Chagas' disease. I. Uptake and mechanisms of destruction of intracellular (amastigote) forms of Trypanosoma cruzi by human neutrophils.

@article{Villalta1983RoleOP,
  title={Role of polymorphonuclear cells in Chagas' disease. I. Uptake and mechanisms of destruction of intracellular (amastigote) forms of Trypanosoma cruzi by human neutrophils.},
  author={Fernando Villalta and Felipe Kierszenbaum},
  journal={Journal of immunology},
  year={1983},
  volume={131 3},
  pages={1504-10}
}
The ability of human polymorphonuclear cells (PMN) to take up and destroy intracellular forms of Trypanosoma cruzi (AMA) was investigated as a part of our efforts to elucidate the mechanisms of clearing of these parasites from infected tissues. PMN were found to take up AMA and destroyed parasites were seen after 30 min of cell-parasite interaction. Under our experimental conditions, the rate of uptake of AMA by PMN was maximal during the first 30 min of interaction. AMA were found to be… CONTINUE READING

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