Role of polyethylene glycol integrity in specific receptor targeting of carbon nanotubes to cancer cells.

@article{Zeineldin2009RoleOP,
  title={Role of polyethylene glycol integrity in specific receptor targeting of carbon nanotubes to cancer cells.},
  author={Reema Zeineldin and M. Al-Haik and Laurie G. Hudson},
  journal={Nano letters},
  year={2009},
  volume={9 2},
  pages={751-7}
}
We demonstrate that dispersion of single walled carbon nanotubes (SWNTs) by ultrasonication with phospholipid-polyethylene glycol (PL-PEG) fragments it, thus interfering with its ability to block nonspecific uptake by cells. However, unfragmented PL-PEG promoted specific cellular uptake of targeted SWNTs to two distinct classes of receptors expressed by cancer cells. Since fragmentation is a likely consequence of ultrasonication, a technique commonly used to disperse SWNTs, this maybe a concern… CONTINUE READING

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