Role of poly [DL-lactide-co-glycolide] in development of a sustained oral delivery system for antitubercular drug(s).

@article{Ain2002RoleOP,
  title={Role of poly [DL-lactide-co-glycolide] in development of a sustained oral delivery system for antitubercular drug(s).},
  author={Q Ain and Sadhna Sharma and Santosh Kumar Garg and Gopal Krishan Khuller},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={239 1-2},
  pages={37-46}
}
An oral formulation based on poly (DL-lactide-co-glycolide) (PLG) microparticles was developed for delivery of antituberculous drugs. PLG entrapped antitubercular drugs when administered orally, were found to release the drugs in a sustained manner. This formulation was found to be stable in the acidic environment of gastric fluid whereas, in the intestinal fluid the drug release was obtained up to 20 days as indicated by in vitro studies. Pharmacokinetic analysis of the data revealed changes… CONTINUE READING

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