Role of poly(ADP-ribose) formation in DNA repair

@article{Satoh1992RoleOP,
  title={Role of poly(ADP-ribose) formation in DNA repair},
  author={Masahiko S. Satoh and Tomas Lindahl},
  journal={Nature},
  year={1992},
  volume={356},
  pages={356-358}
}
THE abundant nuclear enzyme poly(ADP-ribose) polymerase catalyses the synthesis of poly(ADP-ribose) from nicotinamide adenine dinucleotide (NAD+)1–5. This protein has an N-terminal DNA-binding domain containing two zinc-fingers, which is linked to the C-terminal NAD+-binding domain by a short region containing several glutamic acid residues that are sites of auto-poly(ADP-ribosyl)ation6–8. The intracellular production of poly(ADP-ribose) is induced by agents that generate strand interruptions… Expand
Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage.
TLDR
Most but not all poly(ADP-ribose) synthesis could be suppressed without marked inhibition of DNA repair, and prolonged occurrence of long poly( ADP- ribose) chains in consequence to glycohydrolase inhibition did not improve DNA repair. Expand
Role of (ADP-ribose)n catabolism in DNA repair.
TLDR
The results suggest that poly(ADP-ribose) is capable of generating ATP by the concerted action of poly(adP- Ribose) glycohydrolase and ADP- ribose pyrophosphorylase and that this ATP enables repair DNA synthesis. Expand
Poly(ADP-Ribose) polymerase 1 as a key regulator of DNA repair
TLDR
The review summarizes the literature data on the role that PARP1 and PARylation play in DNA repair and particularly in base excision repair; original data obtained in the lab are considered in more detail. Expand
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.
TLDR
The question of its putative nucleo-cytoplasmic shuttling that could enable the tight regulation of pADPr metabolism would contribute to the elucidation of the biological significance of poly(ADP-ribosyl)ation. Expand
Poly(ADP-ribose) polymerase and aging
TLDR
A strong positive correlation was observed between inducible PARP activities in permeablized mononuclear leukocytes of 13 mammalian species and their life spans, suggesting higher PARP specific activity in longer-lived species. Expand
DNA strand break-mediated partitioning of poly(ADP-ribose) polymerase function.
TLDR
The results suggest that the mechanism of poly(ADP-ribose) formation on polymerase molecules entails DNA strand break-mediated partitioning of the polymerase into two functional populations: one bound to the DNA breaks and catalytically active, the other, catalytical inactive, functioning as polymer acceptors. Expand
Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates.
TLDR
The development of a stoichiometric labeling procedure of the enzyme has allowed us to evaluate the catalytic properties of caspase 3 toward mono(ADP-ribosyl)ated PARP at various enzyme:substrate molar ratios and it is shown that low levels of automodification do not inhibit the proteolysis of the substrate. Expand
Poly(ADP-Ribose) Polymerase in Response to DNA Damage
The first observation that paved the way for the discovery of poly(ADP-ribose) and poly(ADP-ribose) polymerase (PARP) was reported by Chambon, et al. in 1963 (30). They found that a particulateExpand
Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing.
TLDR
The data support the proposal that PARP-1 does not play a major role in catalysis of DNA damage processing via either base excision repair pathway, and indicates that in both short- and long-patch BER PARp-1 slows down, rather than stimulates, the repair reaction. Expand
Functional Competition between Poly(ADP-ribose) Polymerase and Its 24-kDa Apoptotic Fragment in DNA Repair and Transcription*
TLDR
The ability of the 24-kDa fragment to inhibit DNA repair, ADP-ribose polymer formation, and damage-dependent up-regulation of transcription may contribute to the apoptotic shift from cell survival to cell death mode. Expand
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References

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TLDR
The polymerization cycle consequently is a major player in the response of cells to DNA breakage, but the game it plays is yet to be explained. Expand
(ADP-ribose)n participates in DNA excision repair
TLDR
It is demonstrated that one function of (ADP–ribose)n is to participate in the cellular recovery from DNA damage, and specific inhibitors of poly(ADP-ribose] polymerase prevent rejoining of DNA strand breaks caused by dimethyl sulphate and cytotoxicity is enhanced thereby. Expand
Influence of poly(ADP-ribose) polymerase on the enzymatic synthesis of SV40 DNA.
TLDR
The binding of PARP at the ends of nascent DNA chains can be displaced by the binding of A1 and PCNA to primer ends, and the inhibition of leading strand synthesis in the monopolymerase system is shown to depend primarily on its DNA binding property rather than on its ability to synthesize poly(ADP-ribose. Expand
ADP-Ribose in DNA Repair: A New Component of DNA Excision Repair
TLDR
This chapter focuses on nuclear ADP-ribosyl transferase, which regulates DNA ligation in DNA repair and in other DNA rearrangements, such as DNA recombination, gene rearrangement, transpositions, sister chromatid exchanges, and chromosomal aberrations. Expand
Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.
TLDR
Poly(ADP-ribose) linked to histone H1 did not seem to cause its dissociation from the chromatin, but it impaired significantly its effect on chromatin condensation, resulting in a relaxed state of poly(ADp-ribosyl)ated polynucleosomes. Expand
[46] Structure of poly(ADP-ribose)
Publisher Summary This chapter focuses on structure of poly(ADP-ribose). A calf thymus nuclear preparation is used as a source of poly(ADP-Rib) [poly(ADP-ribose)] polymerase for preparation andExpand
Presence of poly (ADP-ribose) polymerase and poly (ADP-ribose) glycohydrolase in the dinoflagellate Crypthecodinium cohnii.
TLDR
The results suggest that histones were not relevant to the establishment of poly(ADP-ribose) during evolution and may have been found only in eucaryotes. Expand
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
TLDR
Cl cloning and expression in Escherichia coli of a cDNA fragment encoding the two putative zinc fingers (FI and FII) domain of the human poly(ADP-ribose) polymerase is described, demonstrating that poly( ADP- ribose) polyase contains a type of zinc finger that differs from previously recognized classes in terms of both structure and function. Expand
Poly(ADP-ribose) polymerase is a zinc metalloenzyme.
TLDR
Results suggest that a metal-containing site is involved as part of the interaction of DNA and poly(ADP-ribose) polymerase. Expand
Enzymological properties of poly(ADP-ribose)polymerase: characterization of automodification sites and NADase activity.
TLDR
Automodification greatly altered both enzyme activities, decreasing both polymer synthesis and alternate NADase activity, and there are 28 automodification sites, in contrast to the 15 sites reported to be present in the automodization domain. Expand
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