Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues.

@article{Pettitt2000RoleOP,
  title={Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues.},
  author={Andrew R. Pettitt and Paul D. Sherrington and John C. Cawley},
  journal={Cancer research},
  year={2000},
  volume={60 15},
  pages={4187-93}
}
Although the nucleoside analogues fludarabine and chlorodeoxyadenosine have become important therapeutic agents in chronic lymphocytic leukemia (CLL), their effectiveness is limited by drug resistance. Because such resistance is likely to result from impaired drug-induced apoptosis, it is clearly important to understand the mechanisms involved in this process. Whereas p53 can contribute to the nucleoside-induced killing of CLL cells, recent work from this laboratory and elsewhere has shown that… CONTINUE READING

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Poly(ADP-ribose) polymerase null mouse cells synthesize ADPribose polymers

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