Role of poly(ADP-ribosyl)ation during human spermatogenesis.

@article{Maymon2006RoleOP,
  title={Role of poly(ADP-ribosyl)ation during human spermatogenesis.},
  author={Batia Bar-shira Maymon and Malka Cohen-Armon and Haim Yavetz and Leah Yogev and Beatriz Lifschitz-Mercer and Sandra E Kleiman and Amnon Botchan and Ron Hauser and Gedalia Paz},
  journal={Fertility and sterility},
  year={2006},
  volume={86 5},
  pages={1402-7}
}
OBJECTIVE Genomic stability of cells is known to be linked to their poly(ADP-ribosyl)ation capacity. We aimed to demonstrate, for the first time, the patterns of poly(ADP-ribosyl)ation during human spermatogenesis. DESIGN Retrospective case-control study. SETTING Teaching hospital. PATIENT(S) Azoospermic men who underwent testicular biopsy for sperm recovery. INTERVENTION(S) Testicular biopsy evaluation by immunohistochemistry for the expression of poly(ADP-ribose) polymerase-1 (PARP-1… CONTINUE READING
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