Role of poly(ADP-ribose)synthetase in inflammation.

  title={Role of poly(ADP-ribose)synthetase in inflammation.},
  author={Csaba Szab{\'o}},
  journal={European journal of pharmacology},
  volume={350 1},
  • Csaba Szabó
  • Published 1998 in European journal of pharmacology
Peroxynitrite and hydroxyl radicals are potent initiators of DNA single strand breakage, which is an obligatory stimulus for the activation of the nuclear enzyme poly(ADP-ribose)synthetase (PARS). Rapid activation of PARS depletes the intracellular concentration of its substrate, NAD+, slowing the rate of glycolysis, electron transport and ATP formation. This process can result in acute cell dysfunction and cell necrosis. Accordingly, inhibitors of PARS protect against cell death under these… CONTINUE READING


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