Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment.

  title={Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment.},
  author={Rainer Kiefmann and Kai Heckel and Martina Doerger and Sonja Schenkat and Mechthild Stoeckelhuber and J{\'o}zefa Węsierska-Gądek and Alwin Eduard Goetz},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={285 5},
During systemic inflammation, recruitment and activation of leukocytes in the pulmonary microcirculation may result in a potentially life-threatening acute lung injury. We elucidated the role of the poly(ADP-ribose) synthetase (PARS), a nucleotide-polymerizing enzyme, in the regulation of leukocyte recruitment within the lung with regard to the localization in the pulmonary microcirculation and in correlation to hemodynamics in the respective vascular segments and expression of intercellular… CONTINUE READING