Role of poly(ADP-ribose) polymerase activity in imatinib mesylate-induced cell death

@article{Moehring2005RoleOP,
  title={Role of poly(ADP-ribose) polymerase activity in imatinib mesylate-induced cell death},
  author={Alexandra Moehring and Lara Wohlbold and Walter Erich Aulitzky and Heiko van der Kuip},
  journal={Cell Death and Differentiation},
  year={2005},
  volume={12},
  pages={627-636}
}
Imatinib targets Bcr-Abl, the causative event of chronic myelogenous leukemia (CML), and addresses leukemic cells to growth arrest and cell death. The exact mechanisms responsible for imatinib-induced cell death are still unclear. We investigated the role of poly(ADP-ribose) polymerase (PARP) activity in imatinib-induced cell death in Bcr-Abl-positive cells. Imatinib leads to a rapid increase of poly(ADP-ribosyl)ation (PAR) preceding loss of integrity of mitochondrial membrane and DNA… CONTINUE READING