Role of platelets in tumor cell metastases.

  title={Role of platelets in tumor cell metastases.},
  author={Simon Karpatkin and Edward Pearlstein},
  journal={Annals of internal medicine},
  volume={95 5},
Platelets may have a role in the development of animal tumor metastases. Ultrastructural studies in vivo have shown arrested tumor emboli surrounded by platelets. Several tumor cell lines induce thrombocytopenia in vivo. Certain tumor cells aggregate platelets in vitro. Correlations exist between the ability of some tumor cells to aggregate platelets in vitro and their metastatic potential in vivo. Antiplatelet agents have impaired or altered the spread of certain tumor metastases. It is… CONTINUE READING