Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery.

@article{Fingerle1989RoleOP,
  title={Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery.},
  author={Juergen Fingerle and Reuben F Johnson and Alexander W. Clowes and Mark W. Majesky and Michael A. Reidy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 21},
  pages={
          8412-6
        }
}
Intimal lesion formation was investigated in rats made thrombocytopenic by a single i.p. injection of a polyclonal antibody made against rat platelets that reduced circulating platelet counts to less than 1% of normal. The carotid artery was then denuded of endothelium with a 2 French balloon catheter, after which no platelets were found adhering to the exposed subendothelium. In control animals, platelets adhered instantly to the denuded artery. Six hours after denudation mRNA for ornithine… CONTINUE READING
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