Role of platelets in hypercholesterolemia-induced leukocyte recruitment and arteriolar dysfunction.

@article{Stokes2006RoleOP,
  title={Role of platelets in hypercholesterolemia-induced leukocyte recruitment and arteriolar dysfunction.},
  author={Karen Y. Stokes and Leshanna Calahan and Janice M. Russell and Shelly Gurwara and Dr. D. Neil Granger},
  journal={Microcirculation},
  year={2006},
  volume={13 5},
  pages={
          377-88
        }
}
OBJECTIVE To define the contribution of platelets, specifically platelet-associated P-selectin, to the altered venular and arteriolar responses induced by hypercholesterolemia. METHODS Leukocyte and platelet recruitment in cremasteric venules, and endothelium-dependent relaxation (EDR) in arterioles were determined using intravital videomicroscopy. Wild-type (WT) mice were placed on a normal or high cholesterol diet. Hypercholesterolemic mice were treated with blocking antibodies against… CONTINUE READING

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