Role of platelet-derived growth factor in allograft vasculopathy.

  title={Role of platelet-derived growth factor in allograft vasculopathy.},
  author={Mary C Mancini and J T Evans},
  journal={Annals of surgery},
  volume={231 5},
OBJECTIVE To test the hypothesis that platelet-derived growth factor (PDGF) accelerates the formation of allograft vascular disease. SUMMARY BACKGROUND DATA Allograft vasculopathy, characterized by myointimal hyperplasia of the coronary arteries in the transplanted heart, is the most common cause of late graft failure and death in heart transplant recipients. The cause of the process is unclear, and no treatment exists. PDGF has been implicated in alterations in vascular endothelial biology… CONTINUE READING


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