Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence.

@article{Kubes1990RoleOP,
  title={Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence.},
  author={Paul Kubes and Geoffrey C. Ibbotson and John Russell and John L Wallace and Dr. D. Neil Granger},
  journal={The American journal of physiology},
  year={1990},
  volume={259 2 Pt 1},
  pages={G300-5}
}
The objective of this study was to determine whether platelet-activating factor (PAF) mediates the leukocyte-endothelial cell interactions elicited by ischemia/reperfusion. The rates of adherence and extravasation of leukocytes were monitored in cat mesenteric venules subjected to 60 min of ischemia (blood flow reduced to 20% of control) followed by 60 min of reperfusion. Leukocyte rolling velocity, red blood cell velocity, and vessel diameter were also measured. The experiments were performed… CONTINUE READING

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