Role of platelet‐derived growth factor in wound healing

@article{Pierce1991RoleOP,
  title={Role of platelet‐derived growth factor in wound healing},
  author={Glenn F. Pierce and MD FACS Thomas A. Mustoe and Bruce W. Altrock and T. F. Deuel and Arlen R. Thomason},
  journal={Journal of Cellular Biochemistry},
  year={1991},
  volume={45}
}
Platelet‐derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes‐macrophages and fibroblasts in vitro, cell types considered essential for tissue repair. Therefore, we analyzed the influence of exogenously administered recombinant B chain homodimers of PDGF (PDGF‐BB) on two experimental tissue repair paradigms, incisional and excisional wounds. In both types of wounds, as little as 20‐200… Expand

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TLDR
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TLDR
The results provide an explanation for the beneficial effect of exogenous PDGF in the treatment of wound-healing disorders and suggest that a certain expression level of PDGF and its receptors is essential for normal repair. Expand
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In organ-cultured human corneas, PDGF-BB promotes endothelial wound healing predominantly by cell migration, at least in cornea from senior donors. Expand
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Growth factors and wound healing: platelet-derived growth factor as a model cytokine.
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PDGF added directly to experimental wounds in animals enhances wound healing, which suggests that cytokines will become increasingly important as therapeutic agents in the treatment of wounds in humans. Expand
Amniotic epithelial cells promote wound healing in mice through high epithelialization and engraftment
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Growth factors and extracellular matrix proteins during wound healing promoted with frozen cultured sheets of human epidermal keratinocytes
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References

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Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors.
TLDR
It is shown that the addition of pure PDGF to a wound site involving the epidermis and dermis has little effect on the morphology or biochemistry of the healing wound, and that the synergistic actions of other factors with PDGF are important in the modulation of the wound healing process. Expand
Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms
TLDR
In contrast, PDGF is a more potent chemoattractant for wound macrophages and fibroblasts and may stimulate these cells to express endogenous growth factors, including TGF-beta, which may stimulate new collagen synthesis and sustained enhancement of wound healing over a more prolonged period of time. Expand
In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins
Human platelet-derived growth factor (hPDGF) is likely to be important in stimulating tissue repair, based upon its in vivo chemotactic and stimulatory activities for inflammatory cells andExpand
Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model.
TLDR
The results establish that polypeptide growth factors have significant and selective positive influences on healing of full thickness ulcers in the rabbit. Expand
Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB.
TLDR
The results suggest PDGF requires bone marrow-derived cells, likely wound macrophages, for activity and that it may be useful as a topical agent in postirradiation surgical incisions. Expand
Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor.
TLDR
It is suggested that macrophages might normally act as an intermediate in the induction of procollagen synthesis in fibroblasts of PDGF-treated wounds and that TGF-beta might bypass the macrophage through its capacity to stimulate directly new synthesis of Procollagen type I in fib roblasts. Expand
Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats.
TLDR
The results suggest that the levels of various growth factors, particularly PDGF, may be limiting at wound sites and that supplementation of wounds with these factors can accelerate the rate of new tissue formation. Expand
PDGF and FGF stimulate wound healing in the genetically diabetic mouse.
TLDR
The effectiveness of rPDGF-BB and rbFGF suggest that recombinant growth factors may be useful in the treatment of patients with deficient wound repair, and all parameters of healing but not to a greater extent than either growth factor alone. Expand
Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.
TLDR
Of the six individual factors and nine combinations tested, the combinations of PDGF-2 and IGF-I or PDGF -2 and TGF-alpha were the most potent stimulators of healing in the absence of increased inflammation. Expand
Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.
TLDR
It is demonstrated that PDGF, bFGF, and TGF beta can induce granulation tissue development in normal animals and the responses observed at 10 days reflect a secondary process, possibly mediated by effector cells such as macrophages, lymphocytes, or granulocytes that are attracted into the chamber by each growth factor, rather than a direct effect of the factors themselves. Expand
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