Role of platelet‐derived growth factor in wound healing

  title={Role of platelet‐derived growth factor in wound healing},
  author={Glenn F. Pierce and MD FACS Thomas A. Mustoe and Bruce W. Altrock and Thomas F. Deuel and Arlen R. Thomason},
  journal={Journal of Cellular Biochemistry},
Platelet‐derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes‐macrophages and fibroblasts in vitro, cell types considered essential for tissue repair. Therefore, we analyzed the influence of exogenously administered recombinant B chain homodimers of PDGF (PDGF‐BB) on two experimental tissue repair paradigms, incisional and excisional wounds. In both types of wounds, as little as 20‐200… 
Wound healing. The role of platelet-derived growth factor and transforming growth factor beta.
  • G. Hosgood
  • Medicine, Biology
    Veterinary surgery : VS
  • 1993
Although their mode of action and degree of effect are different, both PDGF and TGF-beta increase the collagen content and early rate of gain of strength in wounds in normal and compromised tissue, however, there is no long-term effect on wound outcome.
Effect of platelet‐derived growth factor on rabbit corneal wound healing
  • M. Stern, K. Waltz, L. Wheeler
  • Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 1995
Results indicate that platelet‐derived growth factor is active in the corneal wound healing process and indicates a more advanced stage of healing in treated versus control wounds at 9 days after the operation.
Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Neovessel and matrix formation and cessation of repair.
Analysis of the composition, quantity, and rate of extracellular matrix deposition within growth factor-treated lapine ear excisional wounds suggest that specific growth factors may selectively regulate components of the repair response by differing mechanisms, offering the potential for targeted therapeutic intervention.
Therapeutic effects of platelet derived growth factor overexpressed-mesenchymal stromal cells and sheets in canine skin wound healing model.
PDGF overexpressed stromal cells or cells sheets can improve cutaneous wound healing in a canine model and especially, the PDGF-CSs presented the highest formation and maturation of granulation tissue among all groups.
Reduced expression of PDGF and PDGF receptors during impaired wound healing.
The results provide an explanation for the beneficial effect of exogenous PDGF in the treatment of wound-healing disorders and suggest that a certain expression level of PDGF and its receptors is essential for normal repair.
Platelet-Released Growth Factors Influence Wound Healing-Associated Genes in Human Keratinocytes and Ex Vivo Skin Explants
A new mechanism that could be responsible for the beneficial wound healing properties of PRGF or related thrombocytes concentrate products such as PRF is described.
Effects of platelet-derived growth factor on endothelial wound healing of human corneas.
In organ-cultured human corneas, PDGF-BB promotes endothelial wound healing predominantly by cell migration, at least in cornea from senior donors.
Thrombin‐activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin‐like growth factor‐1
Thrombin‐activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin‐like growth factor‐1 and activated platelet‐derived growth factor and IGF‐1 receptor tyrosine kinases.
Growth factors and wound healing: platelet-derived growth factor as a model cytokine.
PDGF added directly to experimental wounds in animals enhances wound healing, which suggests that cytokines will become increasingly important as therapeutic agents in the treatment of wounds in humans.
Platelet-Derived Growth Factor Induces SASP-Associated Gene Expression in Human Multipotent Mesenchymal Stromal Cells but Does Not Promote Cell Senescence
Experimental validation of transcriptomic data clearly indicated that PDGF-BB exerted mitogenic and pro-migratory effects on MSCs, and augmented their pro-angiogenic activity, but did not significantly stimulate MSC senescence.


Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors.
It is shown that the addition of pure PDGF to a wound site involving the epidermis and dermis has little effect on the morphology or biochemistry of the healing wound, and that the synergistic actions of other factors with PDGF are important in the modulation of the wound healing process.
Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms
In contrast, PDGF is a more potent chemoattractant for wound macrophages and fibroblasts and may stimulate these cells to express endogenous growth factors, including TGF-beta, which may stimulate new collagen synthesis and sustained enhancement of wound healing over a more prolonged period of time.
In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins
Human platelet-derived growth factor (hPDGF) is likely to be important in stimulating tissue repair, based upon its in vivo chemotactic and stimulatory activities for inflammatory cells and
Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model.
The results establish that polypeptide growth factors have significant and selective positive influences on healing of full thickness ulcers in the rabbit.
Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor.
It is suggested that macrophages might normally act as an intermediate in the induction of procollagen synthesis in fibroblasts of PDGF-treated wounds and that TGF-beta might bypass the macrophage through its capacity to stimulate directly new synthesis of Procollagen type I in fib roblasts.
Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats.
The results suggest that the levels of various growth factors, particularly PDGF, may be limiting at wound sites and that supplementation of wounds with these factors can accelerate the rate of new tissue formation.
PDGF and FGF stimulate wound healing in the genetically diabetic mouse.
The effectiveness of rPDGF-BB and rbFGF suggest that recombinant growth factors may be useful in the treatment of patients with deficient wound repair, and all parameters of healing but not to a greater extent than either growth factor alone.
Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.
Of the six individual factors and nine combinations tested, the combinations of PDGF-2 and IGF-I or PDGF -2 and TGF-alpha were the most potent stimulators of healing in the absence of increased inflammation.
Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.
It is demonstrated that PDGF, bFGF, and TGF beta can induce granulation tissue development in normal animals and the responses observed at 10 days reflect a secondary process, possibly mediated by effector cells such as macrophages, lymphocytes, or granulocytes that are attracted into the chamber by each growth factor, rather than a direct effect of the factors themselves.