Role of plasma membrane lipid composition on cellular homeostasis: learning from cell line models expressing fatty acid desaturases.

@article{Jaureguiberry2014RoleOP,
  title={Role of plasma membrane lipid composition on cellular homeostasis: learning from cell line models expressing fatty acid desaturases.},
  author={Mar{\'i}a S. Jaureguiberry and M Alejandra Tricerri and S. A. Garcia Sanchez and Gabriela S. Finarelli and Mauro Aldo Montanaro and Eduardo Daniel Prieto and Omar J. Rimoldi},
  journal={Acta biochimica et biophysica Sinica},
  year={2014},
  volume={46 4},
  pages={273-82}
}
Experimental evidence has suggested that plasma membrane (PM)-associated signaling and hence cell metabolism and viability depend on lipid composition and organization. The aim of the present work is to develop a cell model to study the endogenous polyunsaturated fatty acids (PUFAs) effect on PM properties and analyze its influence on cholesterol (Chol) homeostasis. We have previously shown that by using a cell line over-expressing stearoyl-CoA-desaturase, membrane composition and organization… CONTINUE READING

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