Role of plasma matrix-metalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients

@inproceedings{Martin2014RoleOP,
  title={Role of plasma matrix-metalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients},
  author={Guadalupe Martin and V{\'i}ctor Asensi and A. Hugo Montes and Julio Collazos and V. Gonz{\'a}lez {\'A}lvarez and Jos{\'e} antonio Cart{\'o}n and Francisco Taboada and Eulalia Valle-Garay},
  booktitle={Scientific reports},
  year={2014}
}
Matrix-metalloproteases (MMPs) and their tissue-inhibitors (TIMPs), modulated by different single nucleotide polymorphisms (SNPs), are critical in sepsis development. Ninety ICU severely septic and 91 ICU uninfected patients were prospectively studied. MMP-1 (-1607 1G/2G), MMP-3 (-1612 5A/6A), MMP-8 (-799 C/T), MMP-9 (-1562 C/T), and MMP-13 (-77A/G) SNPs were genotyped. Plasma MMPs (-1, -2, -3, -8, -9, -10, -13) and TIMPs (-1,-2,-4) were measured. AA homozygotes and A allele carriers of MMP-13… CONTINUE READING

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The authors declare no competing financial interests

  • M. F. Clark, Baudouin, +20 authors 2. Additional information Competing financial interests
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