Role of plasma lipoproteins in modifying the biological activity of hydrophobic drugs.

@article{Wasan1998RoleOP,
  title={Role of plasma lipoproteins in modifying the biological activity of hydrophobic drugs.},
  author={Kishor M. Wasan and Shawn M. Cassidy},
  journal={Journal of pharmaceutical sciences},
  year={1998},
  volume={87 4},
  pages={411-24}
}
The plasma lipoprotein distribution of potential drug candidates is not commonly studied. For some hydrophobic drug candidates, attainment of similar plasma free drug levels has not been associated with uniform production of pharmacological activity in different animal species. It is well-known that plasma lipoprotein lipid profiles vary considerably between different animal species. In addition, human disease states can significantly influence plasma lipoprotein profiles, resulting in altered… CONTINUE READING

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