Role of phosphorylation in desensitization of acetylcholine receptors expressed in Xenopus oocytes.

@article{Hoffman1994RoleOP,
  title={Role of phosphorylation in desensitization of acetylcholine receptors expressed in Xenopus oocytes.},
  author={Pat Hoffman and A D Ravindran and Richard L. Huganir},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 7},
  pages={4185-95}
}
The nicotinic acetylcholine receptor (AChR) is a pentameric complex made up of four types of subunits in the stoichiometry alpha 2 beta gamma delta. These subunits have been shown to be differentially phosphorylated by cAMP-dependent protein kinase (PKA) protein kinase C, and a protein tyrosine kinase. A variety of studies have suggested that phosphorylation of the AChR in vitro and in vivo regulates the rate of desensitization of the receptor. In this study we have used site-specific… CONTINUE READING

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Long-term desensitization of nicotinic acetylcholine receptors is regulated via protein kinase A-mediated phosphorylation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1998
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Convergent regulation of brain sodium channels by CAMP-dependent protein kinase and protein kinase C

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