Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.

@article{Ferguson1995RoleOP,
  title={Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.},
  author={Stephen S. G. Ferguson and Luc M{\'e}nard and Larry S Barak and Walter J Koch and A M Colapietro and Marc G. Caron},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 42},
  pages={24782-9}
}
The beta 2-adrenergic receptor (beta 2AR) belongs to the large family of G protein-coupled receptors. Mutation of tyrosine residue 326 to an alanine resulted in a beta 2AR mutant (beta 2AR-Y326A) that was defective in its ability to sequester and was less well coupled to adenylyl cyclase than the wild-type beta 2AR. However, this mutant receptor not only… CONTINUE READING