Role of phosphorylated ERK in amygdala neuronal apoptosis in single-prolonged stress rats.

  title={Role of phosphorylated ERK in amygdala neuronal apoptosis in single-prolonged stress rats.},
  author={Hao Liu and Haibo Li and Aijun Xu and Quan E Kan and Bin Liu},
  journal={Molecular medicine reports},
  volume={3 6},
Studies have shown that single-prolonged stress (SPS) can induce the apoptotic process in the amygdala. In the present study, we aimed to detect expression of phosphorylated p44/42 extracellular signal-regulated kinase (pERK1/2) and apoptosis-related Bax and Bcl-2 and apoptotic cell death in the amygdala region in SPS rats as well as the relation between pERK1/2 and apoptosis. A total of 75 male Wistar rats were randomly divided into control, SPS and PD98059-SPS groups. Rats in the SPS and… CONTINUE READING
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