Role of phospholipids containing docosahexaenoyl chains in modulating the activity of protein kinase C.

@article{Giorgione1995RoleOP,
  title={Role of phospholipids containing docosahexaenoyl chains in modulating the activity of protein kinase C.},
  author={Jennifer R. Giorgione and Richard M Epand and Csaba Buda and Tibor Farkas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 21},
  pages={9767-70}
}
It is known that the phospholipids of the brain cells of fish are altered during cold adaptation. In particular, the 1-monounsaturated 2-polyunsaturated phosphatidylethanolamines (PEs) increase 2- to 3-fold upon adaptation to cold. One of the most striking changes is in the 18:1/22:6 species of PE. We determined how this lipid affected the bilayer-to-hexagonal-phase transition temperature of 16:1/16:1 PE. We found that it was more effective in lowering this transition temperature than were… CONTINUE READING