Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii.

@article{Walker1983RoleOP,
  title={Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii.},
  author={David H Walker and W T Firth and Jennifer Ballard and Barbara C. Hegarty},
  journal={Infection and immunity},
  year={1983},
  volume={40 2},
  pages={840-2}
}
The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.