Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells.

@article{Kohjimoto1999RoleOP,
  title={Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells.},
  author={Yasuo Kohjimoto and Lori Kennington and Cheryl R. Scheid and Thomas W. Honeyman},
  journal={Kidney international},
  year={1999},
  volume={56 4},
  pages={1432-41}
}
BACKGROUND Oxalate, a common constituent of kidney stones, is cytotoxic for renal epithelial cells. Although the exact mechanism of oxalate-induced cell death remains unclear, studies in various cell types, including renal epithelial cells, have implicated phospholipase A2 (PLA2) as a prominent mediator of cellular injury. Thus, these studies examined the… CONTINUE READING