Role of phosphoinositide 3-kinase in innate immunity.

  title={Role of phosphoinositide 3-kinase in innate immunity.},
  author={K. Hazeki and K. Nigorikawa and O. Hazeki},
  journal={Biological & pharmaceutical bulletin},
  volume={30 9},
  • K. Hazeki, K. Nigorikawa, O. Hazeki
  • Published 2007
  • Biology, Medicine
  • Biological & pharmaceutical bulletin
  • Recent advances in our understanding of the molecular basis of mammalian host immune responses to microbial invasion suggest that the first line of defense against microbes is the recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs). Phosphoinositide 3-kinase (PI3K) is thought to participate in the TLR signaling pathway. The activation of PI3K is commonly observed after stimulation with various TLR ligands. The resultant activation of a serine-threonine protein… CONTINUE READING
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