Role of phosphodiesterase III in the antilipolytic effect of insulin in vivo.

@article{HagstrmToft1995RoleOP,
  title={Role of phosphodiesterase III in the antilipolytic effect of insulin in vivo.},
  author={Eva Hagstr{\"o}m-Toft and Jan Bolinder and Stefan Eriksson and Peter Arner},
  journal={Diabetes},
  year={1995},
  volume={44 10},
  pages={1170-5}
}
The effect of three types of phosphodiesterase (PDE) inhibitors on in vivo antilipolysis was investigated in healthy subjects using a 2-h euglycemic, hyperinsulinemic (40 mU.m-2.min) clamp together with microdialysis of abdominal subcutaneous adipose tissue. During hyperinsulinemia (approximately 330 pmol/l), the circulating glycerol concentration was reduced to approximately 50% of the basal level of 53.2 +/- 3.6 mumol/l, indicating an antilipolytic effect. The decrease in adipose tissue… CONTINUE READING

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