Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion.

@article{Bish2012RoleOP,
  title={Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion.},
  author={Bryan Bish{\'e} and Gulam Hussain Syed and Seth J. Field and Aleem Siddiqui},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 33},
  pages={27637-47}
}
Hepatitis C virus (HCV) RNA replicates within the ribonucleoprotein complex, assembled on the endoplasmic reticulum (ER)-derived membranous structures closely juxtaposed to the lipid droplets that facilitate the post-replicative events of virion assembly and maturation. It is widely believed that the assembled virions piggy-back onto the very low density lipoprotein particles for secretion. Lipid phosphoinositides are important modulators of intracellular trafficking. Golgi-localized… CONTINUE READING
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andRidgway,N.D. (2002)Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein tomodify export from the endoplasmic reticulum

  • J. P. Wyles, C. R. McMaster
  • J. Biol. Chem. 277,
  • 2012

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